Myconutri Sun Agaric (Blaze) 60 tab (högkvalité)

SUN AGARIC 60 CAPSULES (AGARICUS SUBRUFESCENS/BLAZEI)

Japanese name 

Himematsutake

 Chinese name 

Ji Song Rong

(utdrag ur Martin Powell : MEDICINAL MUSHROOMS -A Clinical Guide) 

Although commonly known as A. blazei Murrill (ABM), after a mushroom discovered in 1945 by the mycologist William A. Murrill growing on the lawn of his friend R.W. Blaze in Florida, the mushroom used therapeutically can be traced to spores and samples sent to Japan from the Piedade region of Brazil by a farmer of Japanese descent in 1965. It is now believed that the two are in fact different species with the name Agaricus brasiliensisproposed for the Brazilian Recent analysis however, indicates that this is the same mushroom first identified by Charles Horton Peck in 1893 and called A. subrufescens and that this name should therefore have 

    Although one of the newest medicinal mushrooms, A. subrufescens is rapidly becoming one of the most popular. Reported in a recent survey as being taken by 31% of urological cancer patients in with the fastest growing US sales of any medicinal and one of the three most popular medicinal mushrooms in Taiwan, this relative of the common button mushroom, A. exhibits broad clinical 

    Its polysaccharides include several immunologically active low molecular weight fractions, while an α-1,6 and α-1,4 glucan complex, several polysaccharide-protein complexes, a glucomannan with a main chain of beta 1,2 linked mannopyranosyle residues and a heteropolysaccharide composed mainly of glucose, arabinose and mannose all show anti-tumour Interestingly there appears to be an increase in structural diversity of its polysaccharides with maturation of the fruiting 

    A. subrufescens also contains high levels of lipids, including linoleic acid, oleic acid, stearic acid and 

CANCER - A. subrufescens polysaccharide extracts show strong in vitro and in vivo activity against a range of cancer cell lines, including lung and ovarian cancer, and in vivo studies show positive results for Ehrlich ascites cancer, Sarcoma 180, human ovarian cancer and mouse lung cancer cell lines, as well as synergistic benefits with chemotherapy and 

    In a rat cachexia model A. subrufescens extracts, as well as powdered fruiting body, significantly reduced tumour size and promoted gain in body weight with reduction in AST levels and increased while an in vivo study using severely immunodeficient mice found A. subrufescenspolysaccharides to directly inhibit the growth of prostate cancer cells via an apoptotic pathway and to suppress prostate tumour growth via anti-proliferative and anti-angiogenic mechanisms with the greatest activity found in the broth fraction (compounds extracted from the liquid growth medium in which the mycelium was grown) rather than the mushroom 

    A 2008 study reported significant increases in the NK cell activity of human volunteers given A. subrufescens polysaccharide extract at a dose of 3g/day compared to while Ahn reports increased NK-cell activity and reduced chemotherapy-related side effects (appetite loss, alopecia, emotional stability and general weakness) from A. subrufescens polysaccharide extract in one hundred cervical, ovarian, and endometrial cancer patients treated either with carboplatin plus VP16 (etoposide) or with carboplatin plus 

    In two small Chinese clinical studies, a dose of 20g A. subrufescens fruiting body, taken twice daily as a tea, was reported to improve haematopoietic parameters and treatment outcomes in patients receiving chemotherapy for acute non-lymphocytic leukaemia in one study and improvement in immune status, haematopoietic parameters and quality of life measures in late stage alimentary tract tumours in 

    The closely related A. bisporus shows in vitro anti-aromatase activity, with conjugated linoleic acid identified as the main active component, and Mizuno reports positive clinical results with A. subrufescens in a number of mainly breast cancer patients but at unspecified 

    Although most of the published research strongly supports the use of A. subrufescens in cancer therapy, two studies studies looking at the protective properties of A. subrufescens have been published with negative outcomes (in one A. subrufescens given at 5% of diet did not have a suppressive effect on colon carcinogenesis in rats exposed to dimethylhydrazine, in another an aqueous extract did not affect the development of liver cancer induced by diethylnitrosamine). In a third study A. subrufescens supplementation failed to produce significant change in TNF-α, IFN-γ or IL-10 levels in immunosuppressed mice and it appears that there may be significant variation in activity between different extracts, as well as between different 

DIABETES - To date little clinical data has been published although a 2008 study reported decreases in cholesterol and glucose levels together with increased natural killer cell activity at a dose of 3g/day polysaccharide 

ALLERGIES - As potent immune modulators mushroom polysaccharides can reduce the level of Th2-mediated allergic reactions and A.subrufescens is no exception with Andosan, a proprietary combination of polysaccharide extracts from A. subrufescens (82%), H. erinaceus (15%) and G. frondosa (3%), causing a shift towards a Th1 cytokine profile with consequent reduced risk of allergies and in vitro inhibition of histamine release from mast 

HEPATOPROTECTIVE - There is evidence from a number of small clinical studies indicating possible application of A. subrufescens in the treatment of chronic hepatitis. In one study 1500mg of polysaccharide extract produced significant reductions in liver enzymes in a small number of hepatitis B patients over a 12 month period (AST reduced from 246 to 61 and ALT from 151 to In another A. subrufescens extract reduced GTP in 80% of 20 patients with hepatitis Wang et al also reported wide-ranging benefits in patients with chronic Hepatitis B at a dose of 20g fruiting body twice a day over a 3 month period, including reduction in abdominal distension, fatigue and hepatodynia, together with increased retraction of the liver and 

    One in vivo study also indicates therapeutic potential of A. subrufescens polysaccharide extract for alcoholic liver injury with 100mg/kg body weight producing improvements in liver enzymes as well as liver histology and mitochondrial membrane

MycoNutri Sun Agaric is a professional combination of concentrated hot-water extract free from maltodextrin or other carriers and spray-dried fruiting body powder. Contains >15% beta-glucans together with proteoglycans, arabinoxylans and secondary metabolites.

60 x 500mg capsules (plant cellulose)

2 capsules, 1-3 times a day as a dietary supplement, or as recommended by your health professional